Clinical and epidemiological features of paediatric patients with acute leukaemia in the Clínica Universitaria, Colombia. Clinical series 2011-2014

Main Article Content

Carolina del Pilar Villalba Toquica
Pablo Andrés Martínez Silva
Héctor Acero

Abstract

DOI: 10.1016/j.rcpe.2016.01.002


Objective


To describe the clinical features of acute paediatric leukaemia in a high complexity institution.


Materials and methods


A descriptive, retrospective study was conducted using the clinical registers of paediatric patients with a diagnosis of leukaemia between January 2011 and December 2014. The information was entered into a database in Excel (Microsoft Excel 365) and univariate analysis performed using Stata 12 (Stata Corp LP).


Results


Of all the paediatric patients found in the registers, 90% were diagnosed with Acute Lymphoid Leukaemia (ALL), and 10% with Acute Myeloid Leukaemia (AML). The mean age at diagnosis was 4.8 years, and 90% of them lived in urban areas. The most prevalent symptoms were mucocutaneous pallor–66.7% - and fever–33.3%. Mortality in AML was 100% and 22% in ALL. Symptom remission rate with chemotherapy treatment was 77.8%.


Conclusion


In our population, the paediatric acute leukaemia most often corresponds to the lymphoblastic form, predominantly in females, with a mean age at diagnosis of 3.9 years. They live predominantly in urban areas, and the most significant non-specific clinical manifestations are mucocutaneous pallor, fever, and fatigue


 

Downloads

Download data is not yet available.

Article Details

How to Cite
Villalba Toquica, C. del P., Martínez Silva, P. A., & Acero, H. (2016). Clinical and epidemiological features of paediatric patients with acute leukaemia in the Clínica Universitaria, Colombia. Clinical series 2011-2014. Pediatría, 49(1), 17–22. Retrieved from https://revistapediatria.emnuvens.com.br/rp/article/view/28
Section
Case report

References

1 A.Q. Hernández,A.B. Rosas,R.M. Álvarez,M. Vargas
Neoplasias malignas en los niños del Hospital General de Oaxaca, entre 1999 y 2011
Rev Mex Pediatr, 80 (2013), pp. 136-141

2 D. Niewerth,U. Creutzig,M.B. Bierings,G.J.L. Kaspers
A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia
Blood., 116 (2010), pp. 2205-2214 http://dx.doi.org/10.1182/blood-2010-01-261800
Medline

3 V. Buga-Corbu,A. Glück,C. Arion
Actual biological diagnosis of acute myeloblastic leukemia in children
Journal of Medicine and Life, 7 (2014),

4 G. González,S.L. Salmon,N. Querol,N. Jiménez,M. Sell
Características clinicoepidemiológicas de las leucemias en el niño
MEDISAN, 15 (2011), pp. 1714

5 Canadian Cancer Statistics 2014. Toronto, ON: Canadian Cancer Society; 2014.

6 E. Beutler,M. Lichtman,B. Coller,T. Kipps
Williams Hematology
6th ed., McGraw-Hill, (2001)pp. 1141-1161

7 L.E. Bravo,L.S. García,P. Collazos,P. Aristizabal,O. Ramirez
Descriptive epidemiology of childhood cancer in Cali: Colombia 1977-2011
Colomb Med., 44 (2013), pp. 155-164
Medline

8 A.M. Linabery,J.A. Ross
Trends in childhood cancer incidence in the U.S. (1992-2004)
Cancer., 112 (2008), pp. 416-432 http://dx.doi.org/10.1002/cncr.23169
Artículo | Medline


9 American Cancer Society
Cancer Facts & Figures 2011
American Cancer Society, (2011)

10 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 V1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Disponible en: http://globocan.iarc.fr.

11 A.M. Vera,C. Pardo,M.C. Duarte,A. Suárez
Análisis de la mortalidad por leucemia aguda pediátrica en el Instituto Nacional de Cancerología
Biomédica, 32 (2012), pp. 355-364 http://dx.doi.org/10.1590/S0120-41572012000300006
Medline

12 L.L. Tirado,A. Mohar
Epidemiología de las Neoplasias Hemato-Oncológicas
Cancerología, 2 (2007), pp. 109-120

13 M. Piñeros,C. Pardo,J. Otero,A. Suárez
Protocolo de vigilancia en salud pública de las leucemias agudas pediátricas
Rev Colomb Cancerol, 11 (2007), pp. 219-227

14 J. Wiemels
Perspectives on the causes of childhood leukemia
Chem Biol Interact., 196 (2012),

15 E.J. Chow,S.E. Puumala,B.A. Mueller,S.E. Carozza,E.E. Fox
Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis
Cancer., 116 (2010), pp. 3045-3053 http://dx.doi.org/10.1002/cncr.25099
Medline

16 R.C. Ribeiro,C.H. Pui
Saving the children-improving childhood cancer treatment in developing countries
N Engl J Med., 352 (2005), pp. 2158-2160 http://dx.doi.org/10.1056/NEJMp048313
Medline

17 H. Inaba,M. Greaves,C.G. Mullighan
Acute lymphoblastic leukaemia
Lancet., 381 (2013),

18 Bravo LE, Collazos T, García LE, Gutiérrez A, Carrascal E. Cáncer infantil en Cali, Colombia, 1994-2003. Registro Poblacional de Cáncer en Cali. Cali: Camilo Torres Serna y Cia S.C.S; 2009.

19 M. Zucca,J. Ugalde,F. Salgado,G. Biggio
Leukemia in children and youths of the Azuay province, Ecuador: 2000-2010
International Journal of Environmental Health Research, 23 (2013), pp. 58-65 http://dx.doi.org/10.1080/09603123.2012.699028
Medline

Similar Articles

<< < 4 5 6 7 8 9 10 11 12 13 > >> 

You may also start an advanced similarity search for this article.