Association between altitude and patent ductus arteriosus in preterm newborns from EpicLatino network in the period 2015 - 2020.
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Abstract
Introduction: Several studies have been carried out in the United States, Europe, and Asia on the effect of altitude on the cardiovascular system, but there are not many studies in Latin America, even though it is one of the regions with the most significant variation in altitude due to the changes caused by the Andes Mountains. This is why we want to study the effect of altitude above sea level, since it is believed that newborns born at higher altitudes have a higher risk of persistent ductus arteriosus than those born at lower altitudes.
Materials and methods: Observational, retrospective, and analytical study in which the records of the EpicLatino database were used in the period from 2015 to 2020.
Results: 1243 patients were obtained, 52% were male and 48% female. Gestational age has the most important risk factor, OR 0.51 (0.02-0.03 CI). 62.2% of the units were at an altitude lower than 2000 meters. Altitude and years of study did not modify risk according to logistic regression.
Conclusions: The occurrence of PDA is inversely related to gestational age, with a higher incidence in preterm infants the lower the gestational age, while altitude does not seem to exert any effect.
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References
Alzamora-Castro V, Battilana G, Abugattas R, Sialer S. Patent ductus arteriosus and high altitude. Am J Cardiol [Internet]. 1960;5(6):761–3. Disponible en: http://dx.doi.org/10.1016/0002-9149(60)90052-7. DOI: https://doi.org/10.1016/0002-9149(60)90052-7
Peñaloza D, Arias-Stella J, Sime F, Recavarren S, Marticorena E. The heart and pulmonary circulation in children at high altitudes. Pediatrics [Internet]. 1964;34(4):568–82. Disponible en: http://dx.doi.org/10.1542/peds.34.4.568. DOI: https://doi.org/10.1542/peds.34.4.568
Gross R, Hubbard JP. Surgical ligation of a patent ductus arteriosus: Report of first succesful case. JAMA. 1939;112(8):729 – 731. doi:10.1001/jama.1939.02800080049011. DOI: https://doi.org/10.1001/jama.1939.02800080049011
WalehN, Seidner S, McCurnin D, et al. Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation. Pediatr Res 2011; 70:332. DOI: https://doi.org/10.1203/PDR.0b013e3182294471
Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J, et al. Patent ductus arteriosus of the preterm infant. Pediatrics [Internet]. 2020;146(5):e20201209. Disponible en: http://dx.doi.org/10.1542/peds.2020-1209. DOI: https://doi.org/10.1542/peds.2020-1209
Li J-J, Liu Y, Xie S-Y, Zhao G-D, Dai T, Chen H, et al. Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China. Int J Cardiol [Internet]. 2019;274:106–12. Disponible en: http://dx.doi.org/10.1016/j.ijcard.2018.08.102. DOI: https://doi.org/10.1016/j.ijcard.2018.08.102
Zheng J-Y, Qiu Y-G, Li D-T, He J-C, Chen Y, Cao Y, et al. Prevalence and composition of CHD at different altitudes in Tibet: a cross-sectional study. Cardiol Young [Internet]. 2017;27(8):1497–503. Disponible en: http://dx.doi.org/10.1017/s1047951117000567. DOI: https://doi.org/10.1017/S1047951117000567
Epçaçan S, Bulut MO, Kaya Y, Yücel IK, Çakır Ç, Şişli E, et al. Characteristics and transcatheter closure of patent ductus arteriosus in patients living at moderate to high altitude in Eastern Anatolia. Turk Kardiyol Dern Ars [Internet]. 2019 [citado el 21 de noviembre de 2022];47(6):431–9. Disponible en: https://archivestsc.com/en/characteristics-and-transcatheter-closure-of-patent-ductus-arteriosus-in-patients-living-at-moderate-to-high-altitude-in-eastern-anatolia-163753. DOI: https://doi.org/10.5543/tkda.2019.20805
García A, Moreno K, Ronderos M, Sandoval N, Caicedo M, Dennis RJ. Differences by altitude in the frequency of congenital heart defects in Colombia. Pediatr Cardiol [Internet]. 2016;37(8):1507–15. Disponible en: http://dx.doi.org/10.1007/s00246-016-1464-x. DOI: https://doi.org/10.1007/s00246-016-1464-x
Mirza H, Garcia J, Bell C, Jones K, Flynn V, Pepe J, Oh W. Fluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants. Am J Perinatol. 2021 Nov 23. doi: 10.1055/a-1585-6093. Epub ahead of print. PMID: 34384119. DOI: https://doi.org/10.1055/s-0041-1735623
Ngo S, Profit J, Gould JB, Lee HC. Trends in patent ductus arteriosus diagnosis and management for very low birth weight infants. Pediatrics [Internet]. 2017;139(4):e20162390. Disponible en: http://dx.doi.org/10.1542/peds.2016-2390. DOI: https://doi.org/10.1542/peds.2016-2390