Mammary gland microbiota
Main Article Content
Abstract
DOI: 10.1016/j.rcpe.2015.07.001
To review the literature and to describe the important aspects of mammary gland microbiota using scientific journal databases.Newborns are quickly colonized in their first days of life by different bacteria, which are associated with the beginning of a powerful defense system. It is believed that these bacteria ensure good physical and immunological development.Breast milk is one of the factors that allow early colonization, giving a number of benefits that impact on children's health and the modulation of certain long-term diseases.The way the neonatal intestine colonizes different bacteria and forming its own microbiota is debated. It is assumed to be multifactorial, influenced according to the route of delivery and type of feeding, determining a healthy or altered form where microbiota may modulate different diseases.
The mammary gland microbiota is unique, with multiple factors that lead to its formation.
Its proper establishment will generate protective factors for future life. Oral administration of probiotic milk derivatives open the door to understanding a new way that infant microbiota colonize more efficiently. Lactobacillus reuteri DSM 17939, Bifidobacterium longum and Lactobacillus fermentum CECT 5716 were isolated from the milk of healthy women and several studies confirm that they can be used in human nutrition.
Downloads
Article Details
Creative Commons
License Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
You are free to:
Share - copy and redistribute the material in any medium or format.
Adapt - remix, transform, and build upon the material The licensor cannot revoke these freedoms as long as you follow the license terms.
• Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
• NonCommercial — You may not use the material for commercial purposes.
• ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
• No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
References
Breast milk oligosaccharides: structure-function relationships in the neonate
Annu Rev Nutr, 34 (2014), pp. 143-169 http://dx.doi.org/10.1146/annurev-nutr-071813-105721
Medline
2 P.V. Jeurink,J. van Bergenhenegouwen,E. Jiménez,L.M. Knippels,L. Fernández,J. Garssen
Human milk: a source of more life than we imagine
Benef Microbes, 4 (2013), pp. 17-30 http://dx.doi.org/10.3920/BM2012.0040
Medline
3 C.L. Johnson,J. Versalovic
The human microbiome and its potential importance to pediatrics
Pediatrics, 129 (2012), pp. 950-960 http://dx.doi.org/10.1542/peds.2011-2736
Medline
4 R. Cabrera-Rubio,M.C. Collado,K. Laitinen,S. Salminen,E. Isolauri,A. Mira
The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery
Am J Clin Nutr, 96 (2012), pp. 544-551 http://dx.doi.org/10.3945/ajcn.112.037382
Medline
5 E. Jiménez,S. Langa,V. Martín,R. Arroyo,R. Martín,L. Fernández
Complete genome sequence of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
J Bacteriol, 192 (2010), pp. 4800 http://dx.doi.org/10.1128/JB.00702-10
Medline
6 A. Marcobal,J.L. Sonnenburg
Human milk oligosaccharide consumption by intestinal microbiota
Clin Microbiol Infect, 18 (2012), pp. 12-15 http://dx.doi.org/10.1111/j.1469-0691.2012.03863.x
Medline
7 J.M. Rodriguez,E. Jimenez,V. Merino,A. Maldonado,M.L. Marin,L. Fernandez
Microbiota de la leche humana en condiciones fisiológicas
Acta Pediatr Esp, 66 (2008), pp. 77-82
8 D.S. Newburg,Innate Immunity,Milk. Human
American Society for Nutritional Sciences
Symposium by the American Society for Nutritional Sciences, (2005), pp. 1-5
9 N. León-Cava,C. Lutter,J. Ross,L. Martin
Quantifying the benefits of breastfeeding: a summary of the evidence Washington (DC): PAHO;, (2002),
10 K. Kukkonen,E. Savilahti,T. Haahtela,K. Juntunen-Backman,R. Korpela,T. Poussa
Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial
Pediatrics, 122 (2008), pp. 8-12 http://dx.doi.org/10.1542/peds.2007-1192
Medline
11 R. Martín,S. Langa,C. Reviriego,E. Jimenez,M. Marin,M. Olivares
The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics
Trends Food Sci Technol, 15 (2004), pp. 121-127
12 T.M. Marques,R. Wall,R.P. Ross,G.F. Fitzgerald,C.A. Ryan,C. Stanton
Programming infant gut microbiota: influence of dietary and environmental factors
Curr Opin Biotechnol, 21 (2010), pp. 149-156 http://dx.doi.org/10.1016/j.copbio.2010.03.020
Medline
13 L. Bode
Human milk oligosaccharides: every baby needs a sugar mama
Glycobiology, 22 (2012), pp. 1147-1162 http://dx.doi.org/10.1093/glycob/cws074
Medline
14 D.W. Thomas,F.R. Greer
American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Gastroenterology
Hepatology, and Nutrition Probiotics and prebiotics in pediatrics Pediatrics, 126 (2010), pp. 1217-1231 http://dx.doi.org/10.1542/peds.2010-2548
Medline
15 P.S. Gavilanes,H.A. Manjarrez,A. Cravioto
Inmunoproteccion por leche humana
Rev Mex Pediatr, 69 (2002), pp. 111-119
16 K.M. Hunt,J.A. Foster,L.J. Forney,U.M. Schütte,D.L. Beck,Z. Abdo
Characterization of the diversity and temporal stability of bacterial communities in human milk
PLoS One, 6 (2011), http://dx.doi.org/10.1371/journal.pone.0028413
Medline
17 C.W. Binns,M.K. Lee
Exclusive breastfeeding for six months: the WHO six months recommendation in the Asia Pacific Region
Asia Pac J Clin Nutr, 23 (2014), pp. 344-350
Medline
18 Lodesani G. Programa Mundial de Alimentos. Luchando contra el hambre en el mundo. Los primeros mil dias [en línea]. 2012 04 Oct [consultado 27 Dic 2014]. Disponible en: http://es.wfp.org/noticias/comunicado/los-primeros-mil-di.
19 E.L. Prado,K.G. Dewey
Nutrition and brain development in early life
Nutr Rev, 72 (2014), pp. 267-284 http://dx.doi.org/10.1111/nure.12102
Medline
20 C. Victora
[The thousand days opportunity for nutritional interventions: from conception to two years of life]
Arch Argent Pediatr, 110 (2012), pp. 311-317 http://dx.doi.org/10.5546/aap.2012.318
Medline
21 H. Bergmann,J.M. Rodríguez,S. Salminen,H. Szajewska
Probiotics in human milk and probiotic supplementation in infant nutrition: a workshop report
Br J Nutr, 112 (2014), pp. 1119-1128 http://dx.doi.org/10.1017/S0007114514001949
Medline
22 S. Khanna,P.K. Tosh
A clinician's primer on the role of the microbiome in human health and disease
Mayo Clin Proc, 89 (2014), pp. 107-114 http://dx.doi.org/10.1016/j.mayocp.2013.10.011
Medline
23 C. Urbaniak,J. Cummins,M. Brackstone,J.M. Macklaim,G.B. Gloor,C.K. Baban
Microbiota of human breast tissue
Appl Environ Microbiol, 80 (2014;), pp. 3007-3014 http://dx.doi.org/10.1128/AEM.00242-14
Medline
24 M. Olivares,M.P. Díaz-Ropero,R. Martín,J.M. Rodríguez,J. Xaus
Antimicrobial potential of four Lactobacillus strains isolated from breast milk
J Appl Microbiol, 101 (2006), pp. 72-79 http://dx.doi.org/10.1111/j.1365-2672.2006.02981.x
Medline
25 L. Morelli
Postnatal development of intestinal microflora as influenced by infant nutrition
J Nut, 138 (2008;), pp. 5S-1791S
26 M.W. Groer,A.A. Luciano,L.J. Dishaw,T.L. Ashmeade,E. Miller,J.A. Gilbert
Development of the preterm infant gut microbiome: a research priority
Microbiome, 2 (2014), pp. 38 http://dx.doi.org/10.1186/2049-2618-2-38
Medline
27 L. Fernández,S. Langa,V. Martín,A. Maldonado,E. Jiménez,R. Martín
The human milk microbiota: origin and potential roles in health and disease
Pharmacol Res, 69 (2013), pp. 1-10 http://dx.doi.org/10.1016/j.phrs.2012.09.001
Medline
28 F. Lara-Villoslada,M. Olivares,S. Sierra,J.M. Rodríguez,J. Boza,J. Xaus
Beneficial effects of probiotic bacteria isolated from breast milk
Br J Nutr, 98 (2007), pp. S96-S100 http://dx.doi.org/10.1017/S0007114507832910
Medline
29 A. Donnet-Hughes,P.F. Perez,J. Doré,M. Leclerc,F. Levenez,J. Benyacoub
Potential role of the intestinal microbiota of the mother in neonatal immune education
Proc Nutr Soc, 69 (2010), pp. 407-415 http://dx.doi.org/10.1017/S0029665110001898
Medline
30 E.W. Rogier,A.L. Frantz,M.E. Bruno,L. Wedlund,D.A. Cohen,A.J. Stromberg
Lessons from mother: long-term impact of antibodies in breast milk on the gut microbiota and intestinal immune system of breastfed offspring
Gut Microbes, 5 (2014), pp. 663-668 http://dx.doi.org/10.4161/19490976.2014.969984
Medline
31 M.K. McGuire,M.A. McGuire
Human milk: mother nature's prototypical probiotic food?
Adv Nutr, 6 (2015), pp. 112-123 http://dx.doi.org/10.3945/an.114.007435
Medline
32 R. Martín,M. Olivares,M.L. Marín,L. Fernández,J. Xaus,J.M. Rodríguez
Probiotic potential of 3 Lactobacilli strains isolated from breast milk
J Hum Lact, 21 (2005), pp. 8-17 http://dx.doi.org/10.1177/0890334404272393
Medline
33 M.P. Díaz-Ropero,R. Martín,S. Sierra,F. Lara-Villoslada,J.M. Rodríguez,J. Xaus
Two Lactobacillus strains, isolated from breast milk, differently modulate the immune response
J Appl Microbiol, 102 (2007), pp. 337-343 http://dx.doi.org/10.1111/j.1365-2672.2006.03102.x
Medline
34 D.S. Newburg,W.A. Walker
Protection of the neonate by the innate immune system of developing gut and of human milk
Pediatr Res, 61 (2007), pp. 2-8 http://dx.doi.org/10.1203/01.pdr.0000250274.68571.18
Medline
35 T.O. Brunser,El desarrollo de la microbiota intestinal humana
el concepto de probiótico y su relación con la salud humana
Rev Chil Nutr, 40 (2013), pp. 283-289
36 S.M. Collins,P. Bercik
The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
Gastroenterology, 136 (2009), pp. 2003-2014 http://dx.doi.org/10.1053/j.gastro.2009.01.075
Medline
37 F. Indrio,G. Riezzo,F. Raimondi,A. Di Mauro,R. Francavilla
Microbiota involvement in the gut-brain axis JPGN, 57 (2013), pp. 11-14
38 A. Rosander,E. Connolly,S. Roos
Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain
L reuteri DSM 17938 Appl Environ Microbiol, 74 (2008), pp. 6032-6040 http://dx.doi.org/10.1128/AEM.00991-08
Medline
39 F. Savino,S. Ceratto,A. De Marco,L. Cordero di Montezemolo
Looking for new treatments of Infantile Colic
Ital J Pediatr, 40 (2014), pp. 53 http://dx.doi.org/10.1186/1824-7288-40-53
Medline
40 F. Savino,S. Ceratto,E. Poggi,M.E. Cartosio,M.L. Cordero,A. Giannattasio
Preventive effects of oral probiotic on infantile colic: a prospective, randomised, blinded, controlled trial using Lactabacillus reuteri DSM 17938
Benef Microbes, 6 (2015), pp. 245-251 http://dx.doi.org/10.3920/BM2014.0090
Medline
41 H. Szajewska,E. Gyrczuk,A. Horvath
Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial
J Pediatr, 162 (2013), pp. 257-262 http://dx.doi.org/10.1016/j.jpeds.2012.08.004
Medline
42 V. Sung,H. Hiscock,M.L. Tang,F.K. Mensah,M.L. Nation,C. Satzke
Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial
BMJ, 348 (2014;),
Medline
43 M.M. Grönlund,M. Gueimonde,K. Laitinen,G. Kociubinski,T. Grönroos,S. Salminen
Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease
Clin Exp Allergy, 37 (2007), pp. 1764-1772 http://dx.doi.org/10.1111/j.1365-2222.2007.02849.x
Medline
44 H. Makino,A. Kushiro,E. Ishikawa,D. Muylaert,H. Kubota,T. Sakai
Transmission of intestinal Bifidobacterium longum subsp. longum strains from mother to infant, determined by multilocus sequencing typing and amplified fragment length polymorphism
Appl Environ Microbiol, 77 (2011;), pp. 6788-6793 http://dx.doi.org/10.1128/AEM.05346-11
Medline
45 J.M. Hascoët,C. Hubert,F. Rochat,H. Legagneur,S. Gaga,S. Emady-Azar
Effect of formula composition on the development of infant gut microbiota
J Pediatr Gastroenterol Nutr, 52 (2011), pp. 756-762 http://dx.doi.org/10.1097/MPG.0b013e3182105850
Medline
46 N. Simakachorn,R. Bibiloni,P. Yimyaem,Y. Tongpenyai,W. Varavithaya,D. Grathwohl
Tolerance, safety, and effect on the faecal microbiota of an enteral formula supplemented with pre- and probiotics in critically ill children
J Pediatr Gastroenterol Nutr, 53 (2011), pp. 174-181 http://dx.doi.org/10.1097/MPG.0b013e318216f1ec
Medline
47 R. Martín,S. Langa,C. Reviriego,E. Jimínez,M.L. Marín,J. Xaus
Human milk is a source of lactic acid bacteria for the infant gut
J Pediatr, 143 (2003), pp. 754-758 http://dx.doi.org/10.1016/j.jpeds.2003.09.028
Medline
48 H.E. Lopez
Safety and efficacy of human breast milk Lactobacillus fermentum CECT 5716. A mini-review of studies with infant formulae
Benef Microbes, 17 (2014), pp. 1-6
49 Cárdenas N, Laiño JE, Delgado S, Jiménez E, Juárez Del Valle M, Savoy de Giori G, et al. Relationships between the genome and some phenotypical properties of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk. Appl Microbiol Biotechnol. 2015 Feb. http://dx.doi.org/10.1007/s00253-015-6429-0 PMID: 25661998.
50 F. Lara-Villoslada,S. Sierra,M.P. Díaz-Ropero,J.M. Rodríguez,J. Xaus,M. Olivares
Safety assessment of Lactobacillus fermentum CECT5716, a probiotic strain isolated from human milk
J Dairy Res, 76 (2009), pp. 216-221 http://dx.doi.org/10.1017/S0022029909004014
Artículo | Medline
51 L. Peran,D. Camuesco,M. Comalada,A. Nieto,A. Concha,J.L. Adrio
Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis
Int J Colorectal Dis, (2006;), pp. 21737-21746
52 B. Arribas,M.E. Rodríguez-Cabezas,M. Comalada,E. Bailón,D. Camuesco,M. Olivares
Evaluation of the preventative effects exerted by Lactobacillus fermentum in an experimental model of septic shock induced in mice
Br J Nutr, 101 (2009), pp. 51-58 http://dx.doi.org/10.1017/S0007114508986876
Medline
53 J. Maldonado,F. Cañabate,L. Sempere,F. Vela,A.R. Sánchez,E. Narbona
Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants
J Pediatr Gastroenterol Nutr, 54 (2012), pp. 55-61 http://dx.doi.org/10.1097/MPG.0b013e3182333f18
Medline
54 M. Gil-Campos,M.A. López,M.V. Rodriguez-Benítez,J. Romero,I. Roncero,M.D. Linares
Lactobacillus fermentum CECT 5716 is safe and well tolerated in infants of 1-6 months of age: a randomized controlled trial
Pharmacol Res, 65 (2012), pp. 231-238 http://dx.doi.org/10.1016/j.phrs.2011.11.016
Medline