Necrotizing enterocolitis in a full-term newborn from a mother with HIV, attended in a neonatal intensive care unit, from a third level hospital in the department of Tolima, Colombia

Main Article Content

Martha Letty Arias Penagos
Jose David Gomez Vasco
Iván Alejandro Villalobos

Abstract

Background: Necrotizing Enterocolitis (NEC) is a severe intestinal disorder that primarily affects premature or critically ill newborns. It is characterized by necrosis of the intestinal mucosa, which can lead to severe complications.


Case report: This case study involves a term newborn with several risk factors for developing NEC, including low birth weight and a high risk of vertical HIV transmission due to the mother's infection. The mother, who was 36 years old, had a history of HIV, but did not receive antiretroviral therapy during pregnancy. Additionally, she only attended two prenatal check-ups throughout the entire pregnancy. The baby was delivered via cesarean section due to the mother's infectious disease and breech presentation. After being admitted to the hospital, the baby was fed special formula for premature babies, but on the eighth day of enteral feeding, the baby developed signs of NEC.


Conclusion: It is important to note that Zidovudine treatments in newborns increase the risk of developing NEC, particularly if administered orally. Regular clinical and radiological evaluations are critical for patients diagnosed with NEC, and timely and appropriate medical management should be provided for each case.

Downloads

Download data is not yet available.

Article Details

How to Cite
Arias Penagos, M. L., Gomez Vasco, J. D., & Villalobos, I. A. (2023). Necrotizing enterocolitis in a full-term newborn from a mother with HIV, attended in a neonatal intensive care unit, from a third level hospital in the department of Tolima, Colombia. Pediatría, 56(3), e449. https://doi.org/10.14295/rp.v56i3.449
Section
Case report

References

Duchon J, Barbian ME, Denning PW. Necrotizing Enterocolitis. Vol. 48, Clinics in Perinatology. W.B. Saunders; 2021. p. 229–50. DOI: https://doi.org/10.1016/j.clp.2021.03.002

Bellodas Sanchez J, Kadrofske M. Necrotizing enterocolitis. Vol. 31, Neurogastroenterology and Motility. Blackwell Publishing Ltd; 2019. DOI: https://doi.org/10.1111/nmo.13569

Niño DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: New insights into pathogenesis and mechanisms. Vol. 13, Nature Reviews Gastroenterology and Hepatology. Nature Publishing Group; 2016. p. 590–600. DOI: https://doi.org/10.1038/nrgastro.2016.119

Neu J, Mihatsch W. Recent developments in necrotizing enterocolitis. In: Journal of Parenteral and Enteral Nutrition. SAGE Publications Inc.; 2012. DOI: https://doi.org/10.1177/0148607111422068

Daza W, Ramos N, Silva J. Caso Clínico No 5 (junio 2009): ENTEROCOLITIS NECROTIZANTE.

Neu J, Walker WA. Necrotizing Enterocolitis. New England Journal of Medicine [Internet]. 2011 Jan 20; 364(3):255–64. Disponible en: http://www.nejm.org/doi/abs/10.1056/NEJMra1005408 DOI: https://doi.org/10.1056/NEJMra1005408

Holland AJA, Shun A, Martin HCO, Cooke-Yarborough C, Holland J. Small bowel perforation in the premature neonate: Congenital or acquired? Pediatric Surgery International. 2003 Aug; 19(6):489–94. DOI: https://doi.org/10.1007/s00383-003-0967-8

Gephart SM, Gordon P v., Penn AH, Gregory KE, Swanson JR, Maheshwari A, et al. Changing the paradigm of defining, detecting, and diagnosing NEC: Perspectives on Bell’s stages and biomarkers for NEC. Seminars in Pediatric Surgery. 2018 Feb 1; 27(1):3–10. DOI: https://doi.org/10.1053/j.sempedsurg.2017.11.002

Christensen RD, Lambert DK, Baer VL, Gordon P v. Necrotizing Enterocolitis in Term Infants. Vol. 40, Clinics in Perinatology. 2013. p. 69–78. DOI: https://doi.org/10.1016/j.clp.2012.12.007

Denning TW, Bhatia AM, Kane AF, Patel RM, Denning PW. Pathogenesis of NEC: Role of the innate and adaptive immune response. Vol. 41, Seminars in Perinatology. W.B. Saunders; 2017. p. 15–28. DOI: https://doi.org/10.1053/j.semperi.2016.09.014

Sandoval-Martínez DK, Jaimes-Sanabria MZ, Jiménez-Vargas FL, Chaparro-Zaraza DF, Manrique-Hernández EF, Diana Sandoval CK. Práctica basada en la evidencia Enterocolitis necrotizante Miedo a la muerte. 23. Disponible en: https://doi.org/10.29375/issn.0123-7047 DOI: https://doi.org/10.29375/issn.0123-7047

Akhil Maheshwari, Laura L Corbin, Robert L Schelonka. Neonatal necrotizing enterocolitis. Research and Reports in Neonatology. 2011;1:39–53. DOI: https://doi.org/10.2147/RRN.S23459

Desfrere L, de Oliveira I, Goffinet F, el Ayoubi M, Firtion G, Bavoux F, et al. Increased incidence of necrotizing enterocolitis in premature infants born to HIV-positive mothers.

Maria Pia De Carolis}, Serafina Lacerenza, Daniele De Luca, Iliana Bersani, Simonetta Costa, Costantino Romagnoli. Is neonatal antiretroviral therapy a risk factor for NEC occurrence? The Turkish Journal of Pediatrics. 2010; 52:108–10.

Desfrere L, de Oliveira I, Goffinet F, el Ayoubi M, Firtion G, Bavoux F, et al. Increased incidence of necrotizing enterocolitis in premature infants born to HIV-positive mothers.

Ida González Núñez IMDJMETRJPÁDBC v. Enterocolitis necrosante en un niño prematuro hijo de padres VIH+. 2009.

Thomas Schmitza KW, CFS, EE and MO, a D of N b O and c PP and ICVKCUBGermany. Exposure to HIV and antiretroviral medication. AIDS. 2006;(20:1081–1091.):2–3.

Underwood MA, Gaerlan S, de Leoz MLA, Dimapasoc L, Kalanetra KM, Lemay DG, et al. Human milk oligosaccharides in premature infants: Absorption, excretion, and influence on the intestinal microbiota. Pediatric Research. 2015 Dec 1;78(6):670–7. DOI: https://doi.org/10.1038/pr.2015.162

Javier Torres, Laura Lorena Espinosa, Ángela Marcela García, Alejandra María Mideros, Enrique Usubillaga. Características de recién nacidos con enterocolitis necrotizante en un hospital universitario de tercer nivel en Colombia. Colombia Médica. 2011; 42(0120–8322).

Similar Articles

<< < 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.