Risk factors associated with multisystem inflamatory syndrome temporally associated with COVID infection in San Rafael hospital.
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Abstract
Background: Multisystemic inflammatory syndrome temporarily associated with COVID infection (SIMS-TAC) is a post-infectious complication of COVID 19, the first cases were reported in 2020, consisting of persistent fever, diffuse inflammation and mucocutaneous manifestations, associated with a history of COVID 19 infection. It frequently generates multiorgan dysfunction with cardiac, renal, hematologic, gastrointestinal manifestations, alterations of the general condition such as hypotension, shock and severe systemic inflammation.
Objectives: To identify the risk factors associated with the development of SIMS TAC in patients attended at the Hospital Universitario Clínica San Rafael.
Methods: Case-control study in pediatric patients with SIMS TAC and patients with moderate or severe COVID 19 infection.
Results: Forty-five patients (15 cases and 30 controls) were included. Risk factors for developing SIMSTAC were age older than 5 years (OR 14 CI 95% 1.8-103.6 P 0.001) and obesity (OR 0.09 CI95% 0.01-0.94 P 0.036). As a protective factor, co-sleeping was found (OR 9.7 CI 2.2-42.6 P0.002). The other risk factors showed no significant differences. Lymphadenopathy was a relevant finding in the SIMSTAC group (OR 0.29 CI95% 0.18-0.47 P 0.034). The other laboratory and paraclinical differences are expected for the SIMSTAC group of patients.
Conclutions: The risk factors associated with the development of SIMS TAC were age older than 5 years, overweight or obesity and as a protective factor co-sleeping. The presence of lymphadenopathy should increase the diagnostic suspicion together with the established classificatory criteria.
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